*Doses are commonly-reported figures from public sources, not a recommendation. Educational only.
| Year | Title / venue | Source |
|---|---|---|
| 2026 | Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · preclinical | PMID 41490200 |
| 2022 | Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats Bulletin of experimental biology and medicine · preclinical | PMID 36322304 |
| 2021 | The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress Current reviews in clinical and experimental pharmacology · preclinical | PMID 32621722 |
| 2020 | Functional Connectomic Approach to Studying Selank and Semax Effects Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · preclinical | PMID 32342318 |
| 2019 | Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress Bulletin of experimental biology and medicine · preclinical | PMID 31243679 |
| 2019 | Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats Bulletin of experimental biology and medicine · preclinical | PMID 31625062 |
| 2018 | Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity Protein and peptide letters · preclinical | PMID 30255741 |
| 2017 | GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells Frontiers in pharmacology · preclinical | PMID 28293190 |
| 2017 | Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats Behavioural neurology · preclinical | PMID 28280289 |
| 2016 | Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission Frontiers in pharmacology · preclinical | PMID 26924987 |
| 2015 | [Optimization of the treatment of anxiety disorders with selank] Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · human | PMID 26356395 |
| 2014 | The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action Molecular immunology · preclinical | PMID 24291245 |
Selank (Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro; tuftsin analogue)). Synthetic heptapeptide analogue of the immunopeptide tuftsin. Modulates GABA/serotonin systems, BDNF expression, and enkephalin metabolism; studied as an anxiolytic/nootropic primarily in Russian clinical literature.
Commonly discussed uses: anxiety modulation (research), cognitive support (anecdotal). There is both human and animal/preclinical research, though the depth and quality vary by indication. Note: most uses are not approved indications.
Mechanism: Synthetic heptapeptide analogue of the immunopeptide tuftsin. Modulates GABA/serotonin systems, BDNF expression, and enkephalin metabolism; studied as an anxiolytic/nootropic primarily in Russian clinical literature.
Reported considerations: anecdotal: well tolerated; mild fatigue/nasal irritation (intranasal). There is both human and animal/preclinical research, though the depth and quality vary by indication. Approved/registered as a medicine in Russia; not approved in AU/US/UK. This is not a safety endorsement; safety data for unapproved compounds is incomplete.
Commonly cited ranges (educational reference, not a recommendation): low 250mcg, typical intranasal 250-500mcg/day, high 900mcg/day. Administration: intranasal, subcutaneous. Half-life: short.
Australian status: Not ARTG-registered; research. Approved/registered as a medicine in Russia; not approved in AU/US/UK. General regulatory context: most active peptides are Schedule 4 and require a prescription; import via the Personal Importation Scheme requires a valid Australian prescription for prescription-only goods.
Reconstitution/storage reference: intranasal pre-mixed; SC 2ml BAC per 5-10mg; storage: refrigerated.
Commonly discussed combinations (anecdotal for unapproved compounds): Selank + Semax (nootropic stack, anecdotal). Stacking increases interaction/safety uncertainty.