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Compounds / GHRP-6

GHRP-6

Full name
Growth Hormone-Releasing Peptide-6
Mechanism
Synthetic GH secretagogue (GHS-R agonist). Strong GH release plus pronounced appetite stimulation; moderate cortisol/prolactin effect.
Half-life
~15-60 min
Administration
subcutaneous
Typical dosage*
low: 100mcg · typical: 100-300mcg 1-3x/day · high: 300mcg 3x/day
Researched for
GH-axis research, appetite-stimulation research
Reported side effects
marked hunger, cortisol/prolactin rise, water retention, head-rush, tingling
Interactions
additive with GHRH analogues
Commonly combined
GHRP-6 + CJC-1295 (anecdotal)
Scheduling
🇦🇺 AUNot ARTG-registered; research; WADA prohibited
🇺🇸 USNot FDA-approved; WADA prohibited
🇬🇧 UKNot licensed; WADA prohibited
Regulatory status
WADA-prohibited. Not approved for human therapeutic use.
Recon default
100 mcg typical · 2 ml BAC · refrigerated ~30 days

*Doses are commonly-reported figures from public sources, not a recommendation. Educational only.

12studies
9faqs
growth-hormoneappetitebody-composition

Studies (12)

YearTitle / venueSource
2026Growth hormone releasing peptide-6 (GHRP-6) ameliorates acute lung injury and its subsequent evolvement to interstitial fibrosis
International immunopharmacology · preclinical
PMID 41534456
2025Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation
Journal of nanobiotechnology · preclinical
PMID 41327290
2024Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms
Frontiers in pharmacology · preclinical
PMID 38873418
2015[D-Lys3]-GHRP-6 exhibits pro-autophagic effects on skeletal muscle
Molecular and cellular endocrinology · preclinical
PMID 25450862
2015Detection of GHRP-2 and GHRP-6 in urine samples from athletes
Drug testing and analysis · preclinical
PMID 25809000
2015Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin
Drug testing and analysis · preclinical
PMID 25869809
2014N-aminoimidazolidin-2-one peptidomimetics
Organic letters · preclinical
PMID 24697286
2010GHRP-6 induces CREB phosphorylation and growth hormone secretion via a protein kinase Csigma-dependent pathway in GH3 cells
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · preclinical
PMID 20407870
2006Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure
Clinical science (London, England : 1979) · preclinical
PMID 16417467
1996Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiency
Journal of pediatric endocrinology & metabolism : JPEM · preclinical
PMID 8887178
1996Growth hormone response to GHRH, GHRP-6 and GHRH + GHRP-6 in patients with polycystic ovary syndrome
Clinical endocrinology · preclinical
PMID 8959075
1995Growth hormone secretion after the administration of GHRP-6 or GHRH combined with GHRP-6 does not decline in late adulthood
Clinical endocrinology · human
PMID 7734029

Questions (9)

What is GHRP-6?

GHRP-6 (Growth Hormone-Releasing Peptide-6). Synthetic GH secretagogue (GHS-R agonist). Strong GH release plus pronounced appetite stimulation; moderate cortisol/prolactin effect.

What is GHRP-6 used for?

Commonly discussed uses: GH-axis research, appetite-stimulation research. There is both human and animal/preclinical research, though the depth and quality vary by indication. Note: most uses are not approved indications.

How does GHRP-6 work?

Mechanism: Synthetic GH secretagogue (GHS-R agonist). Strong GH release plus pronounced appetite stimulation; moderate cortisol/prolactin effect.

Is GHRP-6 safe?

Reported considerations: marked hunger, cortisol/prolactin rise, water retention, head-rush, tingling. There is both human and animal/preclinical research, though the depth and quality vary by indication. WADA-prohibited. Not approved for human therapeutic use. This is not a safety endorsement; safety data for unapproved compounds is incomplete.

What is the typical dose of GHRP-6?

Commonly cited ranges (educational reference, not a recommendation): low 100mcg, typical 100-300mcg 1-3x/day, high 300mcg 3x/day. Administration: subcutaneous. Half-life: ~15-60 min.

Is GHRP-6 legal in Australia?

Australian status: Not ARTG-registered; research; WADA prohibited. WADA-prohibited. Not approved for human therapeutic use. General regulatory context: most active peptides are Schedule 4 and require a prescription; import via the Personal Importation Scheme requires a valid Australian prescription for prescription-only goods.

How do you store GHRP-6?

Reconstitution/storage reference: 2ml BAC water per 5mg vial; storage: refrigerated.

What is GHRP-6 commonly stacked with?

Commonly discussed combinations (anecdotal for unapproved compounds): GHRP-6 + CJC-1295 (anecdotal). Stacking increases interaction/safety uncertainty.