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Compounds / GHRP-2

GHRP-2

Full name
Growth Hormone-Releasing Peptide-2 (Pralmorelin)
Mechanism
Synthetic GH secretagogue (GHS-R agonist). Stimulates GH release; also raises appetite, cortisol, and prolactin to a moderate degree.
Half-life
~30-60 min
Administration
subcutaneous
Typical dosage*
low: 100mcg · typical: 100-300mcg 1-3x/day · high: 300mcg 3x/day
Researched for
GH-axis research, diagnostic GH-secretagogue testing (Japan, as pralmorelin)
Reported side effects
increased appetite, cortisol/prolactin rise, water retention, head-rush
Interactions
additive with GHRH analogues
Commonly combined
GHRP-2 + CJC-1295 (anecdotal GH-axis stack)
Scheduling
🇦🇺 AUNot ARTG-registered; research; WADA prohibited
🇺🇸 USNot FDA-approved; WADA prohibited
🇬🇧 UKNot licensed; WADA prohibited
Regulatory status
WADA-prohibited. Approved as a diagnostic agent (pralmorelin) in Japan; not approved in AU/US/UK for therapeutic use.
Recon default
100 mcg typical · 2 ml BAC · refrigerated ~30 days

*Doses are commonly-reported figures from public sources, not a recommendation. Educational only.

12studies
9faqs
growth-hormonebody-composition

Studies (12)

YearTitle / venueSource
2020Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males
Translational andrology and urology · preclinical
PMID 32257855
2015Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin
Drug testing and analysis · preclinical
PMID 25869809
2015Detection of GHRP-2 and GHRP-6 in urine samples from athletes
Drug testing and analysis · preclinical
PMID 25809000
2014Adult growth hormone deficiency: current concepts
Neurologia medico-chirurgica · preclinical
PMID 25070016
2010Determination of growth hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by liquid chromatography/electrospray ionization tandem mass spectrometry
Rapid communications in mass spectrometry : RCM · preclinical
PMID 20552695
2005Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men
The Journal of clinical endocrinology and metabolism · preclinical
PMID 15699539
2004Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN
Drugs in R&D · preclinical
PMID 15230633
2004Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide
Arzneimittel-Forschung · preclinical
PMID 15646370
2002Gateways to clinical trials
Methods and findings in experimental and clinical pharmacology · preclinical
PMID 12092009
1998Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells
Endocrine · preclinical
PMID 9798733
1997Growth hormone-releasing peptides
European journal of endocrinology · preclinical
PMID 9186261
1996GHRP-2, GHRH and SRIF interrelationships during chronic administration of GHRP-2 to humans
Journal of pediatric endocrinology & metabolism : JPEM · human
PMID 8887169

Questions (9)

What is GHRP-2?

GHRP-2 (Growth Hormone-Releasing Peptide-2 (Pralmorelin)). Synthetic GH secretagogue (GHS-R agonist). Stimulates GH release; also raises appetite, cortisol, and prolactin to a moderate degree.

What is GHRP-2 used for?

Commonly discussed uses: GH-axis research, diagnostic GH-secretagogue testing (Japan, as pralmorelin). There is both human and animal/preclinical research, though the depth and quality vary by indication. Note: most uses are not approved indications.

How does GHRP-2 work?

Mechanism: Synthetic GH secretagogue (GHS-R agonist). Stimulates GH release; also raises appetite, cortisol, and prolactin to a moderate degree.

Is GHRP-2 safe?

Reported considerations: increased appetite, cortisol/prolactin rise, water retention, head-rush. There is both human and animal/preclinical research, though the depth and quality vary by indication. WADA-prohibited. Approved as a diagnostic agent (pralmorelin) in Japan; not approved in AU/US/UK for therapeutic use. This is not a safety endorsement; safety data for unapproved compounds is incomplete.

What is the typical dose of GHRP-2?

Commonly cited ranges (educational reference, not a recommendation): low 100mcg, typical 100-300mcg 1-3x/day, high 300mcg 3x/day. Administration: subcutaneous. Half-life: ~30-60 min.

Is GHRP-2 legal in Australia?

Australian status: Not ARTG-registered; research; WADA prohibited. WADA-prohibited. Approved as a diagnostic agent (pralmorelin) in Japan; not approved in AU/US/UK for therapeutic use. General regulatory context: most active peptides are Schedule 4 and require a prescription; import via the Personal Importation Scheme requires a valid Australian prescription for prescription-only goods.

How do you store GHRP-2?

Reconstitution/storage reference: 2ml BAC water per 5mg vial; storage: refrigerated.

What is GHRP-2 commonly stacked with?

Commonly discussed combinations (anecdotal for unapproved compounds): GHRP-2 + CJC-1295 (anecdotal GH-axis stack). Stacking increases interaction/safety uncertainty.